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Publications

19. Elzoghby AO, Ferrone CR, Ferrone S, Nasr ML. Engineered nanomedicines to overcome resistance of pancreatic cancer to immunotherapy. Drug Discov Today. 2022 Nov 08; 28(1):103434. PMID: 36368630.

18. Mori Y, Fink C, Ichimura T, Sako K, Mori M, Lee NN, Aschauer P, Padmanabha Das KM, Hong S, Song M, Padera RF, Weins A, Lee LP, Nasr ML, Dekaban GA, Dikeakos JD, Bonventre JV. KIM-1/TIM-1 is a Receptor for SARS-CoV-2 in Lung and Kidney. medRxiv. 2022 Jan 11. PMID: 32995803; PMCID: PMC7523142.

17. Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Plückthun A, Brown A, Nasr ML, Wagner G. Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs. Nat Struct Mol Biol. 2021 03; 28(3):258-267. PMID: 33633398; PMCID: PMC8176890.

16. Tyukhtenko S, Ma X, Rajarshi G, Karageorgos I, Anderson KW, Hudgens JW, Guo JJ, Nasr ML, Zvonok N, Vemuri K, Wagner G, Makriyannis A. Conformational gating, dynamics and allostery in human monoacylglycerol lipase. Sci Rep. 2020 10 28; 10(1):18531. PMID: 33116203.

15. Padmanabha Das KM, Shih WM, Wagner G, Nasr ML. Large Nanodiscs: A Potential Game Changer in Structural Biology of Membrane Protein Complexes and Virus Entry. Front Bioeng Biotechnol. 2020; 8:539. PMID: 32596222; PMCID: PMC7304444.

14. Nasr ML. Large nanodiscs going viral. Curr Opin Struct Biol. 2020 02; 60:150-156. PMID: 32066086.

13. Wang Y, Kaur P, Sun ZJ, Elbahnasawy MA, Hayati Z, Qiao ZS, Bui NN, Chile C, Nasr ML, Wagner G, Wang JH, Song L, Reinherz EL, Kim M. Topological analysis of the gp41 MPER on lipid bilayers relevant to the metastable HIV-1 envelope prefusion state. Proc Natl Acad Sci U S A. 2019 11 05; 116(45):22556-22566. PMID: 31624123; PMCID: PMC6842640.

12. Zhao Z, Zhang M, Hogle JM, Shih WM, Wagner G, Nasr ML. DNA-Corralled Nanodiscs for the Structural and Functional Characterization of Membrane Proteins and Viral Entry. J Am Chem Soc. 2018 08 29; 140(34):10639-10643. PMID: 30094995; PMCID: PMC6206850.

11. Nasr ML, Wagner G. Covalently circularized nanodiscs; challenges and applications. Curr Opin Struct Biol. 2018 08; 51:129-134. PMID: 29677570; PMCID: PMC6192853.

10. Tyukhtenko S, Rajarshi G, Karageorgos I, Zvonok N, Gallagher ES, Huang H, Vemuri K, Hudgens JW, Ma X, Nasr ML, Pavlopoulos S, Makriyannis A. Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase. Sci Rep. 2018 01 29; 8(1):1719. PMID: 29379013.

9. Hagn F, Nasr ML, Wagner G. Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR. Nat Protoc. 2018 Jan; 13(1):79-98. PMID: 29215632.

8. Obayashi E, Luna RE, Nagata T, Martin-Marcos P, Hiraishi H, Singh CR, Erzberger JP, Zhang F, Arthanari H, Morris J, Pellarin R, Moore C, Harmon I, Papadopoulos E, Yoshida H, Nasr ML, Unzai S, Thompson B, Aube E, Hustak S, Stengel F, Dagraca E, Ananbandam A, Gao P, Urano T, Hinnebusch AG, Wagner G, Asano K. Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5. Cell Rep. 2017 03 14; 18(11):2651-2663. PMID: 28297669.

7. Nasr ML, Baptista D, Strauss M, Sun ZJ, Grigoriu S, Huser S, Plückthun A, Hagn F, Walz T, Hogle JM, Wagner G. Covalently circularized nanodiscs for studying membrane proteins and viral entry. Nat Methods. 2017 01; 14(1):49-52. PMID: 27869813; PMCID: PMC5199620.

6. Lee CM, He CH, Nour AM, Zhou Y, Ma B, Park JW, Kim KH, Cruz CD, Sharma L, Nasr ML, Modis Y, Lee CG, Elias JA. Corrigendum: IL-13Ra2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses. Nat Commun. 2016 11 14; 7:13541. PMID: 27841275.

5. Lee CM, He CH, Nour AM, Zhou Y, Ma B, Park JW, Kim KH, Dela Cruz C, Sharma L, Nasr ML, Modis Y, Lee CG, Elias JA. IL-13Ra2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses. Nat Commun. 2016 09 15; 7:12752. PMID: 27629921.

4. Nasr ML, Singh SK. Radioligand binding to nanodisc-reconstituted membrane transporters assessed by the scintillation proximity assay. Biochemistry. 2014 Jan 14; 53(1):4-6. PMID: 24344975.

3. Nasr ML, Shi X, Bowman AL, Johnson M, Zvonok N, Janero DR, Vemuri VK, Wales TE, Engen JR, Makriyannis A. Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire. Protein Sci. 2013 Jun; 22(6):774-87. PMID: 23553709.

2. Alapafuja SO, Nikas SP, Bharathan IT, Shukla VG, Nasr ML, Bowman AL, Zvonok N, Li J, Shi X, Engen JR, Makriyannis A. Sulfonyl fluoride inhibitors of fatty acid amide hydrolase. J Med Chem. 2012 Nov 26; 55(22):10074-89. PMID: 23083016.

  1. Naidoo V, Karanian DA, Vadivel SK, Locklear JR, Wood JT, Nasr M, Quizon PM, Graves EE, Shukla V, Makriyannis A, Bahr BA. Equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase – dual targets of the endocannabinoid system to protect against seizure pathology. Neurotherapeutics. 2012 Oct; 9(4):801-13. PMID: 22270809.